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GLP-1 receptors are expressed not only in the pancreas but throughout the gut wall and along vagal nerve pathways that modulate emesis and gut motility

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Table 5 Results of a 26-week Open-label Trial of Liraglutide Injection Compared to Sitagliptin (both in combination with metformin) in Adults with Type 2 Diabetes Mellitus a Figure 4 Mean HbA 1c for Adult Patients with Type 2 Diabetes Mellitus who Completed the 26-week Trial and for the Last Observation Carried Forward (LOCF, intent-to-treat) data at Week 26 Combination Therapy with Metformin and Insulin This 26-week open-label trial enrolled 988 adult patients with type 2 diabetes mellitus with inadequate glycemic control (HbA 1c 7-10%) on metformin (≥1,500 mg/day) alone or inadequate glycemic control (HbA 1c 7-8.5%) on metformin (≥1,500 mg/day) and a sulfonylurea